Submitted by Orthopod on April 12, 2020
Experts recommendations are level 5 evidence and includes a lot of uncontrolled bias.
Randomized Controlled Trials (RCTs) are level 1 evidence and excludes risks of bias by randomization and blinding the evaluator and the person received the treatment.
To confirm or infirm the effectiveness of a drug, we need to look at Level 1 evidence including unbiased Randomized Control Trials with double blinding. This will give you an unbiased scientific answer with a pvalue of 0.05 if you select a confidence Interval of 95%.
1 well designed RCT will have more effect in the scientific litterature than 6500 experts recommendation or case reports on drug use or techniques of surgical intervention. Experts opinions or recommendation has little to no value compared to a well designed unbiased RCT.
This is how scientific litterature works and how we base our practice in medecine. Everything we do in our practice is based on well designed Randomized Control trials RCTs such as orthoevidence.com